Program
October, 7th
09 h – Opening ceremony: Maria de Lourdes Aguiar Oliveira (VPPCB/Fiocruz), Tania Araujo-Jorge (director, IOC/Fiocruz), RPT/Fiocruz Representative, Geraldo Pereira (organizing committee)
Session 1
Chair: Roberta Olmo (IOC/Fiocruz)
09:15 h – Opening Conference - Molecular and Cellular Architecture of Granulomas: from monoclonal antibodies to spatial profiling - Robert Modlin (University of California Los Angeles, USA)
10:15 – 10:30 h – Coffee break
Session 2 – New horizons on prevention and control of mycobacterial diseases
Chair: Cristina Pessolani (IOC/Fiocruz)
10:30 - 12 h
- Marcela Henao-Tamayo (Colorado State University, USA) - Strategically targeting mucosal immunity increases the effectiveness of tuberculosis vaccines
- Cynthia Carolina Diaz Acosta (Instituto de Investigaciones en Ciencias de la Salud. Paraguay): Experiences in tuberculosis and leprosy research in Paraguay
12:00 - 13:15 h - Lunch break
Session 3 – Immunometabolic crosstalk in bacterial infections
Chair: Flavio Lara (IOC/Fiocruz)
13:15 - 14:45 h
- Kushboo Borah (Surrey University, UK) - Metabolic flux reprogramming in Mycobacterium tuberculosis-infected human macrophages
- Hyungjin Eoh (Keck School of Medicine of USC, USA): Metabolomics: Chemical biology at the intersection of pathogenesis and antibiotic discovery
- Flavio Lara (Fiocruz, Brazil): Exploring M. leprae metabolism to develop in vitro drug test platforms
14:45 – 15:10 h – Coffee break
Session 4 – Precision medicine: from the lab to the benchside
Chair: Geraldo Pereira (IOC/Fiocruz)
15:10 - 16:40 h
- Irina Giurgea (Sorbonne University, France): Somatic mosaicism in autoinflammatory diseases
- Rogério Lopes Rufino Alves (Rio de Janeiro State University, Brazil): Seeking the Holy Grail, biomarkers in pulmonary fibrosis
- Zilton Vasconcellos (Fiocruz, Brazil): The national network of genomic of inborn innate immunity errors
October, 8th
Session 5 – New visions in inflammatory responses
Chair: Vinícius Cotta Almeida (IOC/Fiocruz)
09:00 - 10:45
- Marcello Rubessa (Roy J. Carver Biotechnology Center, Illinois USA): Spatial Single-Cell Trancriptomics
- Bruno Jorge de Andrade Silva (University of California Los Angeles, USA): "Unraveling T-cell Biology with single-cell RNA-sequencing"
- José Carlos Farias Alves Filho (São Paulo University, Brazil): Control of regulatory T cell differentiation and stability during inflammation
10:45 – 11:00 h – Coffee-break
Session 6 – Translational investigation in complex diseases
Chair: Roberta Soares Faccion (IFF/Fiocruz)
11:00 - 12:00
- Carlos Alberto Almeida de Araújo (Rio Grande do Norte Federal University, Brazil): Integration between clinical research, teaching and outreach activities at the Onofre Lopes University Hospital/Ebserh.
- Kenneth J Gollob (Center for Research in Immuno-oncology, Hospital Israelita Albert Einstein, Brazil) - Identifying Biomarkers and Mechanisms of Immunotherapy Response in Metastatic NSCLC
12:00 – 13:15 h - Lunch break
Session 7 – Inflammatory diseases
Chair: Zilton Vasconcelos (IFF/Fiocruz)
13:15 - 15:00 h
- Sonia Karabina (Sorbonne University, France): Inflammasomes and cell death in health and disease
- Serge Amselem (Hôpital Armand-Trousseau, France): Genetics of rare inflammatory diseases
- Rosane Teles (University of California Los Angeles, USA): Regulation of Lipid-Associated TREM2+ Macrophages in Response to Mycobacterial Infection
15:00 – 15:15 h – Coffee break
Session 8 – Host-immune defense molecules
Chair: Thabatta Rosa
15:15 - 16:45 h
- John Belisle (Colorado State University, USA): Alteration of Host Metabolic Pathways by Mycobacterial Infections
- Vinícius Cotta de Almeida (Fiocruz, Brazil): Genetic and immunotherapeutic targeting of VLA-4 integrin in T cells – implications for studies on inflammatory diseases
October, 9th
Session 9 – Selected Abstracts
Chair: Leticia Lery (IOC/Fiocruz)
9:00 - 10:45 h
Diego Augusto Souza Oliveira (Fiocruz) - Construction of an in vitro culture model for Mycobacterium leprae, aiming for a drug testing platform and production of transgenic strains.
Otto Castro Araújo (Fiocruz) - ApoE biosynthesis in Mycobacterium leprae infection and its role in immunomodulation.
Atta Ur Rahman (Fiocruz) - Indoleamine 2,3 Dioxygenase (IDO) is important for the maintenance of cell metabolic activity in Schwann cells stimulated with Mycobacterium leprae.
Jessica Valeriano (UERJ) -Cannabinoid receptor type 2 agonist GP1a attenuates macrophage activation induced by Mycobacterium bovis-BCG by inhibiting NFKB signaling
Guilherme Iack Pinheiro da Cruz (UFRJ) - Immunoinflammatory role of lipid droplets induced by mycobacteria in dendritic cells: Mechanisms involving DGAT-1 and PGE2
Palloma Porto Almeida (UERJ) - Phenotypic and Functional Alterations in Human Monocytes Induced by Tumor-Derived Extracellular Vesicles
Juliana Pavan Zuliani (Fiocruz) - L-amino acid oxidase from Calloselasma rhodostoma (Malayan Pit Viper) venom interacts with FPR1 receptor and induces vital NETosis in human neutrophils
10:45 – 11:00 h – Coffee break
Session 10 – Making multiomic approaches available for the scientific community
Chair: Mariana Gandini (IOC/Fiocruz) - 11:00 - 11:45
- Milena Hasan (Pasteur Institute, France): State-of-the-art approaches for advanced immunomonitoring in health and disease
Chair: Mariana Gandini (IOC/Fiocruz) - 11:45 - 12:15
- Tiago Titz (Thermo Fischer): Flow Cytometry: Bigfoot Spectral Cell Sorter.
12:15 – 13:30 h - lunch-break
Session 11
Chair: RPT/Fiocruz (activity exclusive for RPT/Fiocruz members)
13:30 - 16 h - Encontro das Plataformas de Citometria da Rede da Rede de Plataformas Tecnológicas Fiocruz - RPT